Mlaignant histiocytosis. Results of combination vincristine-prednisone therapy.

Two patients manifested the typical clinical and pathological features of malignant histiocytosis. Objective remissions of 3 months and 2 months, respectively, were induced by combination chemotherapy with vincristine and prednisone. The patients eventually died from complications of this rapidly progressive and uniformly fatal illness without significant prolongation of survival time. Combined chemotherapy may be useful for induction of remission in this disorder, and suitable maintenance programs should be developed.